FDA approves new targeted breast cancer drug

WASHINGTON (AP) — The Food and Drug Administration has approved a first-of-a-kind breast cancer medication that targets tumor cells while sparing healthy ones.

The drug Kadcyla from Roche combines the established drug Herceptin with a powerful chemotherapy drug and a third chemical linking the medicines together. The chemical keeps the cocktail intact until it binds to a cancer cell, delivering a potent dose of anti-tumor poison.

Cancer researchers say the drug is an important step forward because it delivers more medication while reducing the unpleasant side effects of chemotherapy.

"This antibody goes seeking out the tumor cells, gets internalized and then explodes them from within. So it's very kind and gentle on the patients — there's no hair loss, no nausea, no vomiting," said Dr. Melody Cobleigh of Rush University Medical Center. "It's a revolutionary way of treating cancer."

Cobleigh helped conduct the key studies of the drug at the Chicago facility.

The FDA approved the new treatment for about 20 percent of breast cancer patients with a form of the disease that is typically more aggressive and less responsive to hormone therapy. These patients have tumors that overproduce a protein known as HER-2. Breast cancer is the second most deadly form of cancer in U.S. women, and is expected to kill more than 39,000 Americans this year, according to the National Cancer Institute.

The approval will help Roche's Genentech unit build on the blockbuster success of Herceptin, which has long dominated the breast cancer marketplace. The drug had sales of roughly $6 billion last year.

Genentech said Friday that Kadcyla will cost $9,800 per month, compared to $4,500 per month for regular Herceptin. The company estimates a full course of Kadcyla, about nine months of medicine, will cost $94,000.

FDA scientists said they approved the drug based on company studies showing Kadcyla delayed the progression of breast cancer by several months. Researchers reported last year that patients treated with the drug lived 9.6 months before death or the spread of their disease, compared with a little more than six months for patients treated with two other standard drugs, Tykerb and Xeloda.

Overall, patients taking Kadcyla lived about 2.6 years, compared with 2 years for patients taking the other drugs.

FDA specifically approved the drug for patients with advanced breast cancer who have already been treated with Herceptin and taxane, a widely used chemotherapy drug. Doctors are not required to follow FDA prescribing guidelines, and cancer researchers say the drug could have great potential in patients with earlier forms of breast cancer

Kadcyla will carry a boxed warning, the most severe type, alerting doctors and patients that the drug can cause liver toxicity, heart problems and potentially death. The drug can also cause severe birth defects and should not be used by pregnant women.

Kadcyla was developed by South San Francisco-based Genentech using drug-binding technology licensed from Waltham, Mass.-based ImmunoGen. The company developed the chemical that keeps the drug cocktail together and is scheduled to receive a $10.5 million payment from Genentech on the FDA decision. The company will also receive additional royalties on the drug's sales.

Shares of ImmunoGen Inc. rose 2 cents to $14.32 in afternoon trading. The stock has ttraded in a 52-wek range of $10.85 to $18.10.

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ACLU: US Too Tough on Undocumented Immigrants

The American Civil Liberties Union says United States border security treats people crossing the border illegally to look for work as criminals instead of as desperate people trying to feed their families.

Border security continues to be a central point of the ongoing immigration reform debate, with Republican saying they won't move forward without it and Democrats arguing the borders are already secure.

Now, a 2005 Bush policy known as Operation Streamline, currently in effect, is slowly making its way back into the conversation. Religious, civil rights and legal groups say the program should be reexamined for its civil and human rights impact before any more policies on border security are put into place

"Before we push for border security we need to evaluate existing measures," Joanne Lin, ACLU legislative counsel, told the media Thursday. "Does it make sense to use an expensive program to indiscriminately prosecute migrant workers, people trying to reunite with families and people fleeing violence."

However, Mark Krikorian, executive director for the Center for Immigration Studies, said calling the program a human rights issue is "not legitimate adjective to use."

"Two administrations' Justice Departments have done this for years now," Krikorian said. "I'm pretty confident when weighing the propriety of this kind of action, the consistent, years-long [involvement by] two separate Justice Departments, from two separate parties ... this is not a violation."

Operation Streamline, currently in place in Arizona, Texas and New Mexico, is a partnership between the Department of Justice and the Department of Homeland Security that orders federal criminal charges brought against every person who illegally crosses the border.

Because of the volume of cases, judges often conduct hearings with as many as 80 people at a time, some sitting in the jury box to fit everyone in the room, all pleading guilty in a matter of hours.

"It seriously undermines the American values of due process," said Vicki Gaubeca, director of the ACLU-N.M. Regional Center for Border Rights. "There is no jury because they all plan to plead guilty. That's when you realize it's a rubber-stamp process, a true masquerade of justice. ... Do we really want a justice system that treats people not as individuals with families, jobs and dreams, but as just another unit in a legal assembly line?"

In 2010, in a report to the Human Rights Council, the Vatican came out against the policy, saying, "The Holy See noted that 'Operation Streamline' against irregular migrants should be suspended," until the U.S. finalizes rules on immigration policy.

"From our view, immigrants who cross the border looking for a job, looking for work or trying to reunite with their families are not criminals and they shouldn't be treated as criminals," said Kevin Appleby, director of the Office of Migration Policy and Public Affairs for the U.S. Conference of Catholic Bishops.

Proponents of the policy, like Krikorian, say criminal prosecution discourages folks from trying to illegally enter the United States.

"They should have started it [Operation Streamline] a long time before they did as it is an essential part of deterring illegal immigration," he said. "It really is a crime to sneak into the United States, and we almost never prosecuted illegal entry before Operation Streamline."

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French, Malian forces fight Islamist rebels in Gao

GAO, Mali (Reuters) - French and Malian troops fought Islamists on the streets of Gao and a car bomb exploded in Kidal on Thursday, as fighting showed little sign of abating weeks before France plans to start withdrawing some forces.

Reuters reporters in Gao in the country's desert north said French and Malian forces fired at the mayor's office with heavy machineguns after Islamists were reported to have infiltrated the Niger River town during a night of explosions and gunfire.

French Defense Minister Jean-Yves Le Drian told a news conference in Brussels that Gao was back under control after clashes earlier in the day.

"Malian troops supported by French soldiers killed five jihadists and the situation is back to normal," he said.

In Kidal, a remote far north town where the French are hunting Islamists, residents said a car bomb killed two. A French defense ministry source reported no French casualties.

French troops dispatched to root out rebels with links to al Qaeda swiftly retook northern towns last month. But they now risk being bogged down in a guerrilla conflict as they try to help Mali's weak army counter bombings and raids.

"There was an infiltration by Islamists overnight and there is shooting all over the place," Sadou Harouna Diallo, Gao's mayor, told Reuters by telephone earlier in the day, saying he was not in his office at the time.

Gao is a French hub for operations in the Kidal region, about 300 km (190 miles) northeast, where many Islamist leaders are thought to have retreated and foreign hostages may be held.

"They are black and two were disguised as women," a Malian soldier in Gao who gave his name only as Sergeant Assak told Reuters during a pause in heavy gunfire around Independence Square.

Six Malian military pickups were deployed in the square and opened fire on the mayor's office with the heavy machineguns. Two injured soldiers were taken away in an ambulance.

French troops in armored vehicles later joined the battle as it spilled out into the warren of sandy streets, where, two weeks ago, they also fought for hours against Islamists who had infiltrated the town via the nearby river.

Helicopters clattered over the mayor's office, while a nearby local government office and petrol station was on fire.

A Gao resident said he heard an explosion and then saw a Malian military vehicle on fire in a nearby street.

Paris has said it plans to start withdrawing some of its 4,000 troops from Mali next month. But rebels have fought back against Mali's weak and divided army, and African forces due to take over the French role are not yet in place.

Islamists abandoned the main towns they held but French and Malian forces have said there are pockets of Islamist resistance across the north, which is about the size of France.

CAR BOMB

Residents reported a bomb in the east of Kidal on Thursday.

"It was a car bomb that exploded in a garage," said one resident who went to the scene but asked not to be named.

"The driver and another man were killed. Two other people were injured," he added.

A French defense ministry official confirmed there had been a car bomb but said it did not appear that French troops, based at the town's airport, had been targeted.

Earlier this week, a French soldier was killed in heavy fighting north of Kidal, where French and Chadian troops are hunting Islamists in the Adrar des Ifoghas mountains, which border Algeria.

Operations there are further complicated by the presence of separatist Tuareg rebels, whose rebellion triggered the fighting in northern Mali last year but were sidelined by the better-armed Islamists.

Having dispatched its forces to prevent an Islamist advance south in January, Paris is eager not to become bogged down in a long-term conflict in Mali. But their Malian and African allies have urged French troops not to pull out too soon.

(Additional reporting by Emanuel Braun in Gao, Adama Diarra in Bamako, David Lewis and John Irish in Dakar and Adrian Croft in Brussels; Writing by David Lewis; Editing by Jason Webb and Roger Atwood)

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Asian markets mixed, yen claws back some losses

HONG KONG: Asian markets were mixed on Friday, with Tokyo dragged by a further strengthening in the yen, while the euro faced selling pressure following weak eurozone data.

Losses on Wall Street added to the gloom after disappointing US economic figures, while traders were casting an eye to a general election in Italy at the weekend.

Tokyo fell 0.50 per cent by the break, Hong Kong lost 0.85 per cent and Shanghai was off 0.16 per cent, but Sydney jumped 1.26 per cent and Seoul added 0.23 per cent.

While some markets were lifted by bargain hunting, sentiment was still weak after minutes from the US Federal Reserve's latest policy meeting that stoked fears it could end its huge monetary easing sooner than expected.

Japan's Nikkei was weighed as the yen rose against the dollar and euro, clawing back some of the massive losses it has seen in recent months.

In early Tokyo trade the dollar sat at 93.04 yen, compared with 93.11 yen in New York Thursday. However, the Japanese unit -- which has lost about 17 per cent against the greenback since November -- is much stronger than the 94.00 yen seen at the start of the month.

And the euro fetched 122.78 yen, against 122.81 yen, and well off the 125.50 yen earlier in the week.

The euro bought $1.3189, against $1.3188 in New York Thursday and well short of the $1.3350 on Monday.

The euro came under increased pressure after a leading eurozone growth indicator showed private business activity hit a two-month low in February.

The Purchasing Managers' Index published by London-based Markit fell to 47.3 in February from 48.6 the previous month.

The February figures contrasted sharply with an improvement in the previous three months, which saw it hit a 10-month high in January.

There is nervousness about Sunday's Italian election, which is too close to call and which markets have warned could send the economy back into crisis if there is no clear winner.

Some fear a return of former prime minister Silvio Berlusconi, which could lead to the dismantling of recent economic reforms that have helped draw the country back from economic crisis.

On Wall Street the Dow was down 0.34 per cent, the S&P 500 eased 0.63 per cent and the Nasdaq dropped 1.04 per cent after worse-than-expected US business activity data, while new claims for unemployment benefits rose last week.

Consumer prices also came in flat for a second month in a row in January, underscoring weak inflationary pressures in the world's number one economy.

Meanwhile, traders are becoming increasingly concerned about the lack of progress in Washington on a deal to avert the sequester, deep government spending cuts economists say will slow US growth.

Oil prices rose, with New York's main contract, light sweet crude for delivery in April gaining 17 cents to $93.01 a barrel and Brent North Sea crude for delivery in April adding 17 cents to $113.70.

Gold was at $1,581.30 at 0247 GMT, compared with $1,568.41 late Thursday.

- AFP/ck

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No specific intelligence on Hyderabad twin blasts, Sushilkumar Shinde says

NEW DELHI: Union home minister Sushilkumar Shinde on Friday visited the scene of the twin bomb blasts, which claimed 14 lives and injured over 100, along with Andhra Pradesh chief minister Kiran Kumar Reddy and other senior officials.
"The total dead are 14, total injured is 119. Out of this six are critical," Home minister Sushil Kumar Shinde said at a news conference.

"There was general alert out for the entire national. I don't think the police have failed," said Shinde told the media.

Shinde, who arrived here early Friday, drove to Dilsukhnagar and inspected the blast scene along with Andhra Pradesh governor ESL Narasimhan, chief minister Kiran Kumar Reddy, state home minister Sabita Indra Reddy and other officials.

Director general of police Dinesh Reddy briefed Shinde about the two near-simultaneous blasts in the crowded area.

No group has yet claimed responsibility.

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APNewsBreak: Govs to hear Oregon health care plan

SALEM, Ore. (AP) — Oregon Gov. John Kitzhaber will brief other state leaders this weekend on his plan to lower Medicaid costs, touting an overhaul that President Barack Obama highlighted in his State of the Union address for its potential to lower the deficit even as health care expenses climb.

The Oregon Democrat leaves for Washington, D.C., on Friday to pitch his plan that changes the way doctors and hospitals are paid and improves health care coordination for low income residents so that treatable medical problems don't grow in severity or expense.

Kitzhaber says his goal is to win over a handful of other governors from each party.

"I think the politics have been dialed down a couple of notches, and now people are willing to sit down and talk about how we can solve the problem" of rising health care costs, Kitzhaber told The Associated Press in a recent interview.

Kitzhaber introduced the plan in 2011 in the face of a severe state budget deficit, and he's been talking for two years about expanding the initiative beyond his state. Now, it seems he's found people ready to listen.

Hospital executives from Alabama visited Oregon last month to learn about the effort. And the U.S. Department of Health and Human Services announced Thursday that it's giving Oregon a $45 million grant to help spread the changes beyond the Medicaid population and share information with other states, making it one of only six states to earn a State Innovation Model grant.

Kitzhaber will address his counterparts at a meeting of the National Governors Association. His talk isn't scheduled on the official agenda, but a spokeswoman confirmed that Kitzhaber is expected to present.

"The governors love what they call stealing from one another — taking the good ideas and the successes of their colleagues and trying to figure out how to apply that in their home state," said Matt Salo, director of the National Association of Medicaid Directors.

There's been "huge interest" among other states in Oregon's health overhaul, Salo said, not because the concepts are brand new, but because the state managed to avoid pitfalls that often block health system changes.

Kitzhaber persuaded state lawmakers to redesign the system of delivering and paying for health care under Medicaid, creating incentives for providers to coordinate patient care and prevent avoidable emergency room visits. He has long complained that the current financial incentives encourage volume over quality, driving costs up without making people healthier.

Obama, in his State of the Union address this month, suggested that changes such as Oregon's could be part of a long-term strategy to lower the federal debt by reigning in the growing cost of federally funded health care.

"We'll bring down costs by changing the way our government pays for Medicare, because our medical bills shouldn't be based on the number of tests ordered or days spent in the hospital — they should be based on the quality of care that our seniors receive," Obama said.

The Obama administration has invested in the program, putting up $1.9 billion to keep Oregon's Medicaid program afloat over the next five years while providers make the transition to new business models and incorporate new staff and technology.

In exchange, though, the state has agreed to lower per-capita health care cost inflation by 2 percentage points without affecting quality.

The Medicaid system is unique in each state, and Kitzhaber isn't suggesting that other states should adopt Oregon's specific approach, said Mike Bonetto, Kitzhaber's health care policy adviser. Rather, he wants governors to buy into the broad concept that the delivery system and payment models need to change.

That's not a new theory. But Oregon has shown that under the right circumstances massive changes to deeply entrenched business models can gain wide support.

What Oregon can't yet show is proof the idea is working — that it's lowering costs without squeezing on the quality or availability of care. The state is just finishing compiling baseline data that will be used as a basis of comparison.

One factor driving the Obama administration's interest in Oregon's success is the president's health care overhaul. Under the Affordable Care Act, millions more Americans will join the Medicaid rolls after Jan. 1, and the health care system will have to be able to absorb the influx of patients in a logistically and financially sustainable way.

The federal government will pay 100 percent of the costs for those additional patients in the first three years before scaling back to 90 percent in 2020 and beyond.

"There are a lot of governors who are facing the same challenges we're facing in Oregon," Kitzhaber said. "They recognize that the cost of health care is something they're going to have to get their arms around."

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Arias Challenged On Pedophilia Claim

Accused murderer Jodi Arias was challenged today by phone records, text message records, and her own diary entries that appeared to contradict her claim that she caught her ex-boyfriend, Travis Alexander, looking at pictures of naked boys.

Arias had said during her testimony that one afternoon in January 2008, she walked in on Alexander masturbating to pictures of naked boys. She said she fled from the home, threw up, drove around aimlessly, and ignored numerous phone calls from Alexander because she was so upset at what she had seen.

The claim was central to the defense's accusation that Alexander was a "sexual deviant" who grew angry and abusive toward Arias in the months after the incident, culminating in a violent confrontation in June that left Alexander dead.

Arias claimed she killed him in self-defense. She could face the death penalty if convicted of murder.

Catching Up on the Trial? Check Out ABC News' Jodi Arias Trial Coverage

Today, prosecutor Juan Martinez, who has been aggressive in questioning witnesses throughout the trial, volleyed questions at her about the claim of pedophilia, asking her to explain why her and Alexander's cell phone records showed five calls back and forth between the pair throughout the day she allegedly fled in horror. Some of the calls were often initiated Arias, according to phone records.

Jodi Arias Doesn't Remember Stabbing Ex-Boyfriend Watch Video

Jodi Arias Murder Trial: Testimony About Ex's Death Watch Video

Arias on Ex-Boyfriend's Death: 'I Don't Remember' Watch Video

She and Alexander also exchanged text messages throughout the afternoon and evening at a time when Arias claims the pedophilia incident occurred. In those messages they discuss logistics of exchanging one another's cars that night. Alexander sends her text messages about the car from a church social event he attended that night that she never mentioned during her testimony.

Arias stuck by her claim that she saw Alexander masturbating to the pictures, and her voice remained steady under increasingly-loud questioning by Martinez.

But Martinez also sparred with Arias on the stand over minor issues, such as when he asked Arias detailed questions about the timing and order of events from that day and Arias said she could not remember them.

"It seems you have problems with your memory. Is this a longstanding thing? Since you started testifying?" Martinez asked.

"No it goes back farther than that. I don't know even know if I'd call it a problem," Arias said.

"How far back does it go? You don't want to call them problems, are they issues? Can we call them issues? When did you start having them?" he asked in rapid succession. "You say you have memory problems, that it depends on the circumstance. Give me the factors that influence that."

"Usually when men like you or Travis are screaming at me," Arias shot back from the stand. "It affects my brain, it makes my brain scramble."

"You're saying it's Mr. Martinez's fault?" Martinez asked, referring to himself in the third person.

"Objection your honor," Arias' attorney finally shouted. "This is a stunt!"

Timeline of the Jodi Arias Trial

Martinez dwelled at one point about a journal entry where Arias wrote that she missed the Mormon baptism of her friend Lonnie because she was having kinky sex with Alexander. He drew attention to prior testimony that she and Alexander used Tootsie Pops and Pop Rocks candy as sexual props.

"You're trying to get across (in the diary entry) that this involved a sexual liaison with Mr. Alexander right?" he asked. "And you're talking about Tootsie Pops and Pop Rocks?"

"That happened also that night," Arias said.

"You were there, enjoying it, the Tootsie Pops and Pop Rocks?" he asked again, prompting a smirk from Arias.

"I enjoyed his attention," Arias said.

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French general urges EU to equip "impoverished" Mali army

BAMAKO, Mali (Reuters) - The European Union should complement a mission to train Mali's army, routed by rebels last year, by providing equipment from uniforms to vehicles and communications technology, a French general said on Wednesday.

General Francois Lecointre, appointed to head the EU training mission to Mali (EUTM) that was formally launched this week, said in Bamako equipping the "very impoverished" and disorganized Malian army was as important as training it.

Europe, along with the United States, has backed the French-led military intervention in Mali which since January 11 has driven al Qaeda-allied Islamist insurgents out of the main northern towns into remote mountains near Algeria's border.

European governments have ruled out sending combat troops to join French and African soldiers pursuing the Islamist rebels.

But the EU is providing a 500-strong multinational training force that will give military instruction to Malian soldiers for an initial period of 15 months at an estimated cost of 12.3 million euros ($16.45 million).

While hailing what he called the EU's "courageous, novel, historic" decision to support Mali, Lecointre told a news conference the Malian army's lack of equipment was a problem.

"I know the Malian state is poor, but the Malian army is more than poor," the French general told a news conference, adding that it urgently needed everything from uniforms and weapons to vehicles and communications equipment.

Last year, when Tuareg separatist forces swelled by weapons and fighters from the Libyan conflict swept out of the northern deserts, a demoralized and poorly-led Malian army collapsed and fled before them, abandoning arms and vehicles.

Mali's military was further shaken by a March 22 coup by junior officers who toppled President Amadou Toumani Toure, sowing division among rival army factions. Islamist radicals allied to al Qaeda later hijacked the victorious Tuareg rebellion to occupy the northern half of the country.

In a fast-charging military campaign led by Paris, French and African troops have driven the jihadists out of principal northern towns like Gao and Timbuktu, and are fighting the rebels in the Adrar des Ifoghas mountains.

HUMAN RIGHTS INSTRUCTION

Flanked by Mali's armed forces chief, General Ibrahima Dembele, Lecointre said he was disappointed that a meeting of international donors last month pledged funds for an African military force, known as AFISMA, being deployed in Mali, but included "very few" contributions for the Malian army itself.

"The European Union needs to invest today in the equipping of the Malian army and not just in its training," the general said, adding he would make this point strongly in a report to EU member state representatives early next month.

Asked how much re-equipping the army would cost, he said it would be "much more" than the 12 million euros of EU financing for the training mission, but could not give a precise estimate.

Starting early in April, the EU mission will start instructing Malian soldiers with a plan to train four new battalions of 600-700 members each, formed from existing enlisted men and new recruits.

Lecointre said the EU training would include instruction in human rights. Demands for this increased after allegations by Malian civilians and international human rights groups that Malian soldiers were executing Tuaregs and Arabs accused of collaborating with Islamist rebels.

The European training contingent is drawn from a range of European countries, but the main contributors would be France, Germany, Italy, Spain and Britain, EUTM officers said.

Mali's army has received foreign training before - several battalions that fled before the rebels last year were trained by the U.S. military and the leader of the March 22 coup, Captain Amadou Sanogo, attended training courses in the United States.

Dembele said U.S. training failed to forge cohesion among Malian units and he hoped the EU training would achieve this.

The United States, which halted direct support for the Malian military after last year's coup, could eventually resume aid if planned national elections in July fully restore democracy to the West African country.

Washington is providing airlift, refuelling and intelligence support to the French-led military intervention in Mali. ($1 = 0.7479 euros)

(Reporting by Pascal Fletcher; Editing by Jason Webb)

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It's 'The Oscars', now officially

LOS ANGELES: They are the 85th Academy Awards, the climax of Hollywood's awards season, this coming weekend -- except officially they're not. This year, they've been rebranded to "The Oscars."

The Academy of Motion Picture Arts and Sciences (AMPAS), which organizes Tinseltown's biggest awards, did not confirm the change revealed by show co-producer Neil Meron, who said "85th Academy Awards" was too "musty."

But it seems it's true, for this year at least: references to Academy Awards and that it's the 85th show -- a significant anniversary, one might have thought -- quietly disappeared from official AMPAS materials a few weeks ago.

"We're rebranding it," Meron told entertainment news website TheWrap in an interview with co-producer Craig Zadan this week, days before Hollywood's finest take to the red carpet at the Dolby Theatre on Sunday.

"We're not calling it 'The 85th annual Academy Awards,' which keeps it mired somewhat in a musty way. It's called 'The Oscars'," he said, adding that he believed the new approach would continue in years to come.

An AMPAS spokeswoman declined to confirm the change, but said: "We use Academy Awards and the Oscars interchangeably. We'll begin considering next year's marketing campaign in the spring."

Last year's Oscars poster was quite clearly emblazoned with "The 84th Academy Awards." This year's shows a picture of smiling host Seth MacFarlane under "The Oscars," in gold.

The Oscars organizers are widely understood to be targeting a younger audience for their annual show -- and "Family Guy" creator MacFarlane could be part of that strategy.

Two years ago a clear get-the-young-viewers ploy, with actors James Franco and Anne Hathaway jointly fronting the show, was widely criticized, with Franco's wooden performance drawing particular scorn.

Last year Eddie Murphy was initially set to host but pulled out at the last minute after an embarrassing gay slur row involving one of the producers, and the Academy fell back on veteran Billy Crystal, who hosted for a ninth time.

- AFP/sf

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Railway Budget likely to announce 100 new trains

NEW DELHI: Railways is planning to introduce about 100 trains, including AC double deckers, new passenger services and extension of services to cater to the demands of various states in the Rail Budget 2013-14.

As far as rolling stock programme is concerned, the announcement will be made for manufacturing of 4200 new coaches including 600 LHB coaches in the Rail Budget.

While provision for manufacturing of 670 new locomotives including 20 LNG locos will be made, the budget will also account for manufacturing of about 16,000 new wagons.

"The focus of the Rail Budget this year is on providing more amenities to passengers. Attempts have been made to cater to the demands of all regions including Northeast as there were representations for new trains from various states," sources in railway ministry said.

While services of some express trains have been extended, frequency of certain popular trains have also been increased keeping the demand of people's representatives in mind.

"About 100 new trains will be announced in the budget," the sources said.

Last year, Railways had announced launching of 175 trains including passenger services.

Maintaining cleanliness and hygiene in trains and stations, providing quality linen, upgradation of fire-fighting arrangements and new facilities for differently abled persons are some of the measures likely to be announced by Railway Minister Pawan Kumar Bansal in his maiden budget speech on February 26.

The proposal to provide braille stickers inside coaches for assisting visually impaired passengers are among the measures likely to be announced by Bansal.

A total of 543 trains have been identified for providing on board house keeping scheme (OBHS) to keep toilets and coaches clean and hygienic.

Railways have also proposed to set up about 10 mechanised laundries to improve supply of clean and quality linens on trains.

New measures for fire suppression system in AC coaches and pantry cars, which are more fire prone, are likely to be announced in the Railway Budget.

Cash-strapped railways, which has sought Rs 38,000 crore as general budgetary support (GBS) from the Finance Ministry, is likely to get about Rs 28,000 crore for the next fiscal.

Last year, it had got Rs 24,000 crore as GBS.

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